Listen to Georgi (aka Haidut) and I discuss weight loss, sugar, and fat in the real organism on Episode #9 of The Generative Energy Podcast!

“The true method of knowledge is experiment.” —William Blake

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01:19 – The dumbing down of the nutrition scene
02:23 – The latest drugs for obesity inhibit fat oxidation
03:29 – De novo lipogenesis is not an active pathway in humans
04:09 – Fat gain due to high stress hormones and free fatty acids
05:15 – Sugars and protein stimulate the metabolism
06:21 – The Randle cycle – competition between sugar and fat
07:40 – Inhibiting lipolysis supports the oxidation of sugar
08:11 – Low-carbers not accounting for organismic complexity
08:50 – Do you have to liberate fat to lose it?
11:36 – Cutting carbohydrates decreases the liver’s glycogen
12:40 – “A ketogenic diet is an abomination.”
13:31 – Examples from the animal world
14:50 – Hibernation, Randle cycle, and insulin resistance
15:30 – Bears prefer sugar-rich foods upon waking from hibernation
16:18 – The good news – appears to be easily reversible
16:50 – The low-carb emphasis on phosphate – risky?
17:38 – The benefits of sugar (specifically fructose)
18:40 – Fructose depletes phosphate, lowers PTH, PTH can cause diabetes
19:07 – Starches can increase endotoxin and serotonin
19:59 – Calcium, phosphate, PTH, and cancer
21:04 – Sugar oxidation and fat oxidation are different animals
22:44 – Fructose increases palmitic acid and helps the liver create cholesterol for the synthesis of protective steroids
23:18 – Fructose protects animals from endotoxin
24:04 – How could people be so wrong about fructose?
26:15 – Prolactin — a good marker for stress?
29:34 – Blood tests – prolactin, cholesterol, TSH, etc.
31:11 – Georgi, where can we find more of your work on the internet this week?

*There was a lot of window noise, which made this episode difficult to edit, my apologies. Also, Georgi should have a new mic for the next episode.

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28 COMMENTS

  1. "Fructose has great ability to replenish glycogen, to stop the stress..", oh, how awesome is fructose. I just cannot express my sadness and don't even know where to start.

    95% people on western diet NEVER have empty glycogen stores. They eat diet, that's high in carbs, their glycogen stores are always full. If they eat glucose and fructose together – what happens to fructose then? Only one way to go, since there is glucose around and glycogen is full – DE NO VO LIPOGENESIS.

    Stress on low carb causes cortisol and this is somehow bad thing? What narrative are you on ? If you have no glucose, you need ketones to fuel the brain. Cortisol is fantastic at breaking fatty acids from adipose tissue, author mentioned it himself. That fatty acids then get's converted to ketones. Which is adaptive and cortisol has a beneficial role here. It's what's called EUSTRESS, good form of stress.

    Also – when fasted or on low carb – you do not burn muscle. Studies have proven it all over again. Growth hormone is stimulated which preserves muscle mass. Even though there are some protein loss – IT"S GOOD THING, because that protein is most likely from your skin or connective tissue, which you want to get rid of. THINK ABOUT IT.

    And misinterpretation of Randle cycle is mindblown – it saves glucose for the brain on low carb. You are insulin resistant at that moment, and it's a GOOD THING, it's called glucose sparing effect. There is no reason to eat glucose to restore "sensitivity". You just keep eating fat and protein, become satiated earlier, result in caloric deficit, take some extra fat with the help of cortisol from adipose, burn it off in the cell. There is no need for insulin if you are not consuming glucose. And YOU DON'T NEED TO CONSUME GLUCOSE! It's non essential macronutrient, it's not a question for discussion. And we certainly don't want to overexpose ourselves to insulin. It's an anabolic hormone, that makes people fat via many mechanisms. It's also ageing hormone. And so on.

    This interview justifies low carb from many standpoints of view, it's that the author operates with many dogmas in his head.

  2. Knowledgeable, but he's got some holes in his logic. Beans and other plant-based foods have LOW phosphorus bioavailability, thus adjusting this "so called high phosphate" aspect. I question his promotion/approval of dairy products and the calcium aspect as well.

  3. I almost can't believe what I'm hearing

    Some of this seems obvious, some of it seems absurd. Can this be verified with peer reviewed evidence?

    Omega 3 fats, for instance, have quite a few studies showing their effects on protection from heart disease, improvements in insulin management etc

    If sugar is not inflammatory and does not produce ROS etc, how are the anti inflammatory effects of the keto diet occuring?

    Why does sugar stimulate a stress response?

  4. The biggest driver of stress and cortisol is something people often overlook; sleep. The quickest way to skyrocket your cortisol is to simply not sleep enough, that's it, it's just that easy. Diabetes and obesity can often be tied to people who don't sleep enough or have piss poor sleeping habits.

  5. so how can you eat in America? isnt everything enrich in PUFAs and sugars combined. Where is the dietary information with descriptive lists of what a person can or cannot eat. Also wouldnt people get tired of eating this way? wouldnt they start to miss eating burgers pizza and burritos lol

  6. For understanding… FFA inhibit glucose oxidation via the randle effect which decreases insulin sensitivity, upregulates stress hormones, and leads to weight gain? Where I don't understand is where does the weight/fat actually come from if it takes 500g of carbohydrate to induce de-novo fatty acid synthesis? With that amount of carbohydrate intake necessary for it to become fat tissue, what other materials do become that fat? Pufa and protein being the building blocks just seems like a lot of fat would go unaccounted for there.Thanks for any clarification, keep up the good work!

  7. Great video, just wonderful! I was just wondering about the rice eating Asian cultures Haidut mentioned having little body hair. That would seem at odds with many Middle Eastern cultures who are have large rice consumption but are the hairiest people in the world.

  8. Definitely enjoyed all the information in this. From my own real-world experience, when I went to boot camp several years ago, I was following a Paleo diet but decided that when I got there, I was going to eat as healthy as possible without "stressing out over it." I didn't drink milk, but I had at least one banana at every single meal, usually an apple at lunch and dinner, whatever fruit came by for dessert, usually melons, canned peaches, or occasionally sliced oranges, when my mind would celebrate. My mind also celebrated the one time I got sweet potatoes. Between that and the innumerable packets of Sunbutter I put down, I can't even imagine the amount of sugar I was putting away, and I lost a scary amount of weight. I attribute a lot of the weight loss to the stress response I was having, but let's be honest, that's a ton of fruit.

    Having said that, I was in a unique situation. A lot of the first part of this episode talked about the significance of stress, and correct me if I misheard, but I thought I heard Georgi say that several studies indicated that the type of diet didn't matter so much as the level of stress, including both dietary (from low carb) and even mental stress. Where do lifestyle changes, such as getting enough sleep, practicing yoga, or doing meditation, fit into this spectrum?

    I am absolutely looking forward to the episode on digestion.

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